Responsible investmentSimple footnote as part of text text added as footnote in the title

has taken equity markets by storm. testAlthough its penetration into fixed income markets has been slower, it is picking up speed there too.testYet one area remains overlooked – government bonds.That’s a major oversight. After all, governments set the rules and regulations that companies and individuals follow, and without their support and investment, the world will not be able to tackle its most pressing problems – climate change in particular.Global average temperatures are already 1.2C higher than they were in the pre-industrial era. And even if countries deliver on all the carbon emission-cutting pledges made so far, that degree of warming is expected to double to 2.4C by 2100.1Fixed income investors have a key part to play in providing the capital required to keep climate change in check. While individually, investors have a negligible influence on government policy, collectively they can make a real difference – after all, the investment community holds USD88 trillion in bonds issued by governments and their agencies.
Here is the external Deloit linkhttps://www.deloitte.com/us/en/insights/industry/health-care/proactive-care-medicare-savings.html

Article page footnote text added before title Immunotherapy before surgery

In two landmark presentations, we saw the relevance of using immunotherapy approachesFootnote ahead of surgery (known as neoadjuvant immunotherapy) in some types of cancer. In the NICHE trial, a neoadjuvant combination of ipilimumab and two doses of nivolumab treatment in 20 patients with a high mutational load colorectal cancer resulted in a major pathological response in 19 out of the 20 patients. Moreover, Professor Christian Blank (of the Netherlands Cancer Institute) presented ground-breaking results from the NADINA trial, which examined the efficacy of neoadjuvant immunotherapy versus adjuvant immunotherapy (i.e. post-surgery) in treating stage III melanoma. The study involved 423 patients. The key findings highlight that the neoadjuvant approach greatly improves outcomes for patients, with a 68% reduction in risk of recurrence of the disease. For the patients with major responses, the results were particularly promising: a 95% event-free survival rate at 12 months. These results could redefine the treatment of stage III melanoma.

Use of GLP-1 receptor agonists to reduce cancer risk Use of GLP-1 receptor agonists to reduce cancer risk

Ozempic _and Wegovy ^are the best-known examples of drugs called GLP-1 receptor agonists (GLP-1 RAs), which mimic the action of GLP-1, a hormone made by the small intestine. These drugs were originally used to treat type 2 diabetes, and recent landmark studies also support their use for weight loss. At ASCO, a retrospective study in patients with a body mass index of at least 35kg/m2 (i.e. severely obese) found that treatment with GLP-1 RAs appears to lower the risk of developing obesity-related cancer, with results similar to bariatric surgery. Specifically, when compared with those who received no treatment, the researchers discovered a 39% reduction in cancer risk for 13 types of such cancers.

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First ChapterPotential CustomersThird chapterFirst ChapterWhen USM, a leading Swiss manufacturer of iron products and window mechanisms, decided to build a new factory, it wanted to transform its manually oriented production plant into a modern industrial enterprise. It knew that its old-fashioned processes could not compete with companies which had already modernised, but the transformation had an unexpected consequence. Instead of continuing to make window mechanisms, the company ended up producing a modular furniture system which has become a modern design classic.USM is a family-owned business founded by Ulrich Schärer in 1885 as a hardware and locksmith’s business in Münsingen, close to Switzerland’s capital city of Bern. His grandson Paul Schärer took over the company in 1961 after studying engineering, and he realised that USM needed to build a larger factory to become more competitive. So he collaborated with architect Fritz Haller to realise his vision of a flexible factory built using a steel modular construction system which could easily be expanded as the business grew.The new factory included a pavilion to house USM’s offices, and the two men wanted to design a furniture system that was flexible enough to adapt to a growing business when it needed more office space. In 1963, they created a pioneering furniture product known as USM Haller Modular Furniture, sold at first for office use but later for home use, and now exported to more than 40 countries around the world.Alexander Schärer, Paul’s son who joined USM in 1993 and led its foreign expansion, says there was an irony in this evolution. “The company intended to continue selling its window mechanisms to the architects who used them for the homes they built, while commercialising the new modular factory construction system. But the window mechanisms were less in demand as factory buildings became air-conditioned, as had its own. So the modular furniture which was intended to be a byproduct of the new building system became the company’s main product.”The system is not complicated. It uses three basic steel and chrome components: spherical joints which connect tubes together, and support panels which come in a variety of attractive colours. So elegant is the design that the USM Haller Modular Furniture has been included in the Architecture and Design collection of New York’s prestigious Museum of Modern Art (MoMA).In 1969, the production and sale of USM Haller Modular Furniture began, with the first large contract signed for the headquarters of Rothschild Bank in Paris. This required substantial retooling to make the manufacturing profitable, but it had two important beneficial consequences: details of the new furniture were featured in architectural journals and caught the attention of architects; and a fashion show was staged in the bank, which attracted a lot of newspaper coverage for the futuristic furniture.Potential CustomersPotential customers were attracted to the pavilion on the Münsingen factory site to see the new furniture system, and USM started recruiting dealers to sell it. Outlets were opened in 20 Swiss cities, starting with Zurich, Lausanneand Bern. And in 1975, a German subsidiary was opened in Bühl to set up a similar dealer network to Switzerland’s.Bühl to set up a similar dealer network to Switzerland’s. “The USM system started as an insider product in Switzerland,” says Alexander Schärer. “It was originally taken up by architects who wanted it to be exclusive to their offices. But it became a branded product in Switzerland in the late 1980s and is now a mainstream product.”The marketing in Germany focused heavily on offices at first, furnishing big banks, lottery companies and other businesses. But in 2008 when banks started collapsing in the financial crisis, USM sold more into the home market, which had already grown in Switzerland.“Offices often buy directly from the company, but homeowners tend to visit showrooms or go to dealers because their orders are generally smaller. Our website has a Configurator section which allows buyers to create their own designs, though many residential customers turn to dealers for guidance to perfect them. In Switzerland 90 per cent of our residential customers go for custom-designed pieces.”It is unusual for homes to be fully fitted out with USM furniture, he adds: residential customers tend to buy it just for parts of their homes, though the system’s flexibility means it can easily be expanded or changed if desired. However, he recalls that one wealthy client fitted out a full Chicago penthouse with the company’s products to provide a home for their artwork and memorabilia.Business developments have led to changes in the ranges of modular furniture. Less filing space is needed in offices, for example, because much more information is now stored online. But there is more demand for partitions and land-scaping for creative spaces and privacy in open-plan offices.The USM business has three main production functions. The main one is manufacturing the modular components, which all takes place at the Münsingen factory and employs just under half of the company’s 400 or so employees. The second function is assembly, which is handled by around a quarter of the employees globally. And a new company is being set up in Leipzig in Germany to carry out the assembly for all of Europe except Switzerland, where it is still done at Münsingen.The third function covers sales, marketing and distribution, which is done by the around a third of the staff, working with a network of more than 400 qualified sales partners. The numbers have grown over the years, as projects for homes are typically smaller than those for offices, needing more people to support sales and the shorter delivery deadlines that residential customers expect. The margins on those smaller projects is better, however, and are likely to rise as the share of sales online increases.One of the attractions of USM’s modular furniture formost buyers is the length of its useful life. Swiss manufacturing is synonymous with precision, quality and dependability, and the modular furniture components are made with first-class materials to the finest level of craftsmanship. Part of the company’s DNA is that its furniture can last 20 years or more, with no need to repair or replace parts –unlike other cheaper self-assembly furniture brands.Third chapterOne of the company’s first patent registrations was for the very durable ball joint used to connect the chrome tubesand the support panels in a rigid framework. The ball joint also contributes to the adaptability of the modular products, which can be altered or extended when adapting to current and future needs while retaining the same degree of robustness. This was recognised in 2018 with cradle to cradle (C2C) certification for two of USM’s ranges whose design, use and recycling of resources mean they are used effectively over their long life cycle.With concerns rising about the impact of global warming, USM is also taking steps to reduce its carbon footprint. Its powder-coating paint process, which generates a lot of heat, has been moved to a basement that therefore requires no heating in winter and minimal cooling in summer. The company has installed solar power on the roof of its largest building to substantially reduce its demand for electricity in summer. It is also building a new heating plant fuelled by locally sourced wood pellets rather than oil, which will reduce the carbon footprint of its heating by around 75 per cent.USM remains a private company and has no problem in raising funds when finance is needed, says Alexander Schärer. Decision-making takes much less time in a family business, which can be vital if restructuring or closing some operations is urgently required. And there are plenty of challenges that he would like to tackle in managing a branded business, attracting the creative people which the company always needs, and increasing the online business from its relatively low 10 per cent share.USM has stood out for its modularity vision and value over more than 50 years. With its Swiss manufacturing strengths and products which can be adapted to suit changing times and needs, he believes there is much more that can be achieved for many years to come.

Adding this first footnote more we use Large Language Models – at work or at home – the more potentially Add secound footnote data we release out into the world, putting the onus on keeping that information safe. At the same time, agentic AI is paving the way for ever more sophisticated cyberattacks. Generic phishing emails with poor spelling are easy to spot. But an authentic-looking message from Human Resources or a realistic voice note can deceive even the most vigilant among us. Machines hacking machines are an emerging area of concern in data protection. All this presents a big challenge for the cyber security industry – but also a big opportunity for security companies that can harness AI’s power to protect organisations and consumers. There is a hacker infiltration every 39 seconds, and millions of records are stolen through breaches everyday.https://deepstrike.io/blog/how-many-cyberattacks-happen-every-dayIt’s not surprising, therefore, that global spending on cyber security is forecast to grow by nearly 14% a year, according to Gartner. The challenge is to develop machines and software that can https://www.lipsum.com

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